Building Employment Skills Through Therapy for Veterans (BEST Vet)

Building Employment Skills Through Therapy for Veterans (BEST Vet)

Detailed Description:

The objective of the current proposal is to evaluate whether integrated cognitive behavior therapy (iCBT) can improve engagement and success in an existing Supported Employment (SE) program among the most functionally disabled patients with schizophrenia/schizoaffective disorder. The iCBT condition also includes computerized cognitive remediation. The primary specific aim is to determine whether iCBT will significantly improve work outcomes at post-treatment to a greater extent than Usual Care (UC) in low functioning patients with schizophrenia/schizoaffective disorder who join the SE program. The secondary aims are to evaluate the whether iCBT will significantly improve work outcomes at 6 month follow-up relative to UC, and whether iCBT will improve functional outcomes post-treatment and at follow-up relative to UC in subjects who join the SE program.


Ages Eligible for Study:  

18 Years to 65 Years   (Adult)

Sexes Eligible for Study:  


Accepts Healthy Volunteers:  



Inclusion Criteria:

·         Diagnosis of DSM-IV schizophrenia or schizoaffective disorder (SCID)

·         Severe/extreme functional disability [World Health Organization Disability Assessment Scale (WHODAS) score > 50]

·         Stabilized in the community (3 months since last hospitalization)

·         Receiving treatment at the Veterans Administration

·         Minimal engagement in psychiatric rehabilitation services (just psychiatrist and therapist/case management in the last 6 months)

·         Eligible for and willing to be enrolled in Supported Employment program

·         Age 18 to 65

·         Proficient in English

·         Able to give informed consent

Exclusion Criteria:

·         Neurologic disease or damage that would make the diagnosis of schizophrenia questionable

·         Current opioid or stimulant dependence (SCID)

·         Not appropriate due to safety concerns (based on risk assessment)

  Contacts and Locations

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Please refer to this study by its identifier: NCT01992913


Contact: Steven L Sayers, PhD

(215) 823-5196


United States, Pennsylvania

Philadelphia VA Medical Center, Philadelphia, PA


PhiladelphiaPennsylvaniaUnited States, 19104

Contact: David W Oslin, MD    215-823-5870   

Principal Investigator: Steven L. Sayers, PhD         

Sponsors and Collaborators

VA Office of Research and Development


Principal Investigator:

Steven L. Sayers, PhD

Philadelphia VA Medical Center, Philadelphia, PA